Société Française de Bioinformatique

Mots-Clés

sarcoma RNA-seq ChIP-seq single cell

Description

A 12-months position in computational biology is available for a highly-motivated post-doctoral fellow or fully trained bionformatician, for the analysis of molecular profiling data (including single-cell data) of pediatric and adult transcription factor-driven sarcoma.

Institutional context: The Institut Curie and Institut Gustave Roussy are major international players in cancer research and treatment. The objective of their Research Center is to comprehensively decipher cancer biology thanks to the analysis of patient samples and preclinical models, and to conversely use basic research discoveries to improve the diagnosis, prognosis and treatment of cancer as part of a continuum between research and care. The close proximity between clinicians, translational research groups and basic researchers offers a highly stimulating and collaborative research environment. Olivier Delattre’s team, within Institut Curie U830, has a worldwide expertise in studying cancer genetics, diversity and plasticity of childhood tumors. Sophie Postel-Vinay’s group, within Gustave Roussy U981 INSERM, studies chromatin remodeling and DNA repair with a focus on therapeutic innovation. Both groups work closely to their respective Departments of Medical Oncology and Drug Development for validating the predictors and implementing new targets in therapeutic trials.

Objectives: The successful candidate will study neoepitopes and specific regulatory mechanisms in the sarcoma subtypes of interest, using RNA sequencing, ChIP-Seq and single-cell RNA-Seq data from public and in-house databases. The candidate will be under the supervision of Dr Josh Waterfall, and will work closely with Olivier Delattre and Sophie Postel-Vinay.

 Required skillset: Applicants should have the following skills:

• be fluent in English, knowledge of French is not required
• demonstrated experience in bioinformatics research, with prior experience in analyzing NGS data
• PhD diploma, Grandes Ecoles or similar experience
• strong publication record and excellent communications skills
• highly motivated to work with a multi-disciplinary team combining computational approaches with experimental biology