Mots-Clés

immunogenetics immunoinformatics AIRR anlaysis adaptive immunity

Description

The context :

IMGT®, the international ImMunoGeneTics information system®, is the world reference in immunogenetics and immunoinformatics. Through several research projects, IMGT allows the exploration of immunoglobulin (IG) or antibodies, T cell receptors (TCR), Major Histocompatibility Complex (MH), IG superfamily and MH superfamily. The internship, the details of which are described below, will take place in a context dedicated to the study of the immune receptor repertoire (BCR and TCR), in individuals (1) without any particular pathology and (2) with a viral infection.

The internship:

Many studies highlight the correlation between immune repertoire diversity and an individual's immune status (healthy, infection, autoimmune disease, etc.) [2]. These studies use healthy or non-pathological repertoires as controls to represent physiological diversity, from which any deviation can potentially be associated with pathology. Accuracy in identifying the baseline immune repertoire diversity can significantly impact the reliability and interpretability of all downstream analyses that provide valuable information for diagnostic, therapeutic and clinical indications.

The missions:

As part of the internship, the student will be responsible for :

• Characterise a collection of directories in different states (non-pathological and viral infection) with ImmuneRef [3], a tool for analysing several immune repertoires.

• Use the R programming language to code functions allowing a large-scale comparison of directories analysed by ImmuneRef (creation and analysis of networks).

• Add other repertoire characterisation metrics to the ImmuneRef environment.

The student will be welcomed in the framework of IMGT. He/she will be trained internally in the basics of immunogenetics and repertoire analysis and the discipline's commonly-used tools and data structures.

Expected skills:

Comfortable with: R, bash and Git

Collaborative and Inquisitive Mindset