Mots-Clés

Formal Modeling Systems Biology Reaction Networks Diabetes

Description

Type 2 Diabetes (T2D) is the main epidemic of this century. A recent hypothesis of medical research is that an important cause of T2D may be the abnormal regulation of glucose absorption in the small intestine. Despite of many experimental observations, this question remains poorly investigated. The objective of the present project is to investigate the regulation of glucose absorption at the cellular level of the intestin. First, a simple model of glucose absorption regulation, based on existing ones and on new experimental data, will be proposed. The aim is to decypher the relative contribution of the two main glucose transporters SGLT1 and GLUT2. Second, a more detailed model will be proposed to study the cellular trafficking of glucose transporters and its impact on glucose absorption.