Mots-Clés

Network bioinformatics, de novo genes, small peptides, network rewiring, function prediction

Description

Postdoc Offer (2023 – 2026)

Rewiring of cellular networks by de novo peptides

A postdoctoral position is available at the TAGC laboratory (Theories and Approaches of Genomic Complexity, Inserm-Aix-Marseille University, Marseille, France) in the Network Biology group (@NetBioinfoMRS). The successful candidate will explore the interactome of small peptides (sPEPs) using computational approaches. More particularly, how sPEPs products of de novo gene rewire cellular networks will be investigated. The project will include both data analysis and methodological development.

This project stands in the context of a collaborative international project involving 3 research groups (US, Germany, and France).

Required Qualification:

- You have a PhD degree with a focus in Network Biology, Bioinformatics, Computational Biology, Complex Systems or related fields.

- You are an accurate and precise worker and possess strong analytical problem-solving skills (creative, critical, thinking out-of-the-box).

- You are proficient in data analysis utilizing cutting-edge computational methods, coupled with extensive experience in applying statistical techniques to biological data.

- You master R and Python programming languages, and you are familiar with Linux-based high-performance computing environments.

- You are able to communicate effectively and collaborate as part of an interdisciplinary team (bioinformaticians, biologists, computational scientists).

- You are able to compose and deliver comprehensive presentations at scientific meetings and prepare research articles for peer-reviewed publications.

You can work independently to drive projects forward, yet you are also a team player.

A strong familiarity with FAIR principles and an expertise in developing highly distributable software, including R packages, Python modules, and computational workflows, will be a valuable asset.

Salary will be based on Inserm guidelines for Postdoctoral scholars and commensurate with qualifications and experience. Appointments — possibly starting in December 2023 — will be for up to 3 years.

For additional information about the research program and this opportunity, please contact Dr. Christine Brun (christine-g.brun@inserm.fr, https://tagc.univ-amu.fr/en/users/brun-christine)

About the lab

The TAGC laboratory (Theories and Approaches to Genomic Complexity, https://tagc.univ-amu.fr/, @TAGC_U1090), is a joint Inserm and Aix-Marseille University research unit located in the Luminy Campus, next to the well-renowned Calanques National Park (https://www.calanques-parcnational.fr/en). In the lab, we seek to decipher the biological mechanisms leading once disrupted, to pathologies such as cancer, cardiomyopathies, systemic inflammation or infectious diseases like malaria. Over the years, the Network Biology group has developed network-based approaches and algorithms to understand the organization of cellular processes and protein multifunctionality by exploiting molecular interaction networks (protein-protein and protein-RNA).