Mots-Clés

data scientist next generation sequencing cytometry structural biology cryoEM

Description

5 years Tenure track with research and teaching, to become university professor

Location : Laboratoire IMoPA (UMR 7365 CNRS-UL), Nancy

Research profile :

The UMR IMoPA seeks to recruit a bioinformatician and/or data scientist with skills in computational biology. Multiple ImoPA teams (1, 2, 3, 4 and 6) generate large quantities of data in different biological domains, whose treatment, synthesis and exploitation depend increasingly on the creation of effective computational analysis pipelines. This is particularly the case for sequencing data (transcriptomics, RNA epigenetics, etc.), data generated by proteomics approaches, and screening assays in glycobiology. Furthermore, IMoPA’s structural biology teams are evolving towards the use of cryo-EM, which will require specialized informatics tools for image processing, 3D structure classification, and structural analysis by protein structure prediction/modeling. These efforts will be re-inforced by the ongoing consolidation of a four-laboratory consortium (IMoPA, DynAMic, LPCT and the LORIA) in integrative structural biology. Finally, multiparameter flow cytometry, which is utilized by several teams in the ImoPA and surounding labs, requires the use of increasingly sophisticated software for (non-)supervised analysis of multiple cellular populations including rare populations, notably in the context of immune-phenotyping of patients or genetically-modified animals. This type of expertise is also increasingly critical for single cell analysis, which was recently established within IMoPA, for identifying cellular heterogeneity within populations initially viewed as homogeneous.

Teaching project

Teaching in bioinformatics (analytical methods, big data exploitation, pipeline construction, etc.) and data science/computational biology applied to biology and human health. The recruited person may instruct at the undergraduate level (‘licence’) within the Health Science (‘Science de la santé’) curriculum, and at the Masters level (Masters Life Sciences [Sciences du Vivant] or Engineering for Health [Ingénierie de la Santé]), for example in the molecular biology and cellular biology specializations.