Mots-Clés

RNA-seq, scRNA-seq, virus respiratoires, épithéliums primaires, CRISPR

Description

2 Postdoctoral positions on innate immunity and respiratory viruses including 1 for a bioinformatician willing to learn and do some wet lab work

Institut de Recherche en Infectiologie de Montpellier (IRIM), France

The Interferon and Antiviral Restriction Lab, led by Caroline Goujon, is recruiting 2 postdoctoral fellows on innate immunity and respiratory viruses to work on the ERC-funded InVIRium project, for up to 4 and 5 years, respectively:

- 1 postdoctoral fellow with a strong expertise in the fields of innate immunity and virology (experience in BSL-3 lab, and with respiratory viruses required). Experience in 3D-cultures of primary airway epithelia would be a massive plus.

- 1 postdoctoral fellow with skills in bioinformatics (scRNA-seq and NGS analyses) and at least some training in wet lab experiments or a strong will to learn (tissue culture, virology methods)

The InVIRium project aims at understanding the relationships between respiratory viruses and their host cells, using highly pertinent models of airway epithelia cultured at the air-liquid interface, with a major focus on respiratory viruses (coronaviruses, influenza viruses and respiratory syncytial virus) and on interferon-induced antiviral restriction.

Our lab is located at the ‘Institut de Recherche en Infectiologie de Montpellier’ (IRIM), which is a CNRS / Montpellier University co-funded research center dedicated to the study of infectious diseases. The IRIM offers access to all the facilities required for cutting-edge research, including BSL2 and BSL3 labs, state-of-the-art cell imaging and microscopy facilities, flow cytometry and cell sorting, genomics, and proteomics platforms. The IRIM constitutes a friendly and international working environment, with staff and students coming from around 25 different countries. Montpellier is a lovely city in the South of France, 15 km away from the Mediterranean sea and offering an amazing quality of life.

For more information on the host lab and institute:

http://www.irim.cnrs.fr/index.php/en/researchh/teams/interferon-and-antiviral-restriction

The 2 positions will be available from the beginning of 2024. Candidates should send their application, CV and contact information for at least 2 referees to: caroline.goujon@irim.cnrs.fr

Selected publications:

Rebendenne A., …, Doench J.G.@, and Goujon C.@ Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Nature Genetics, 2022. 

Bonaventure B., …, Goujon C.@ The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses. EMBO Reports, 2022.

McKellar J., … Moncorgé O. @, and Goujon C.@. An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses. Journal of Biological Chemistry, 2023.

Rebendenne A., …, Moncorgé O.@, Goujon C.@. SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells. Journal of Virology, 2021