Revenir à la liste des offres d'emplois Development of a workflow for processing lipidomic unbiaised data. Stage · Stage M2 · 6 mois Bac+5 / Master Plateau MetaToul-Lipidomique, I2MC-Inserm U1297-UPS, Hopital Rangueil, 31432 Toulouse · Toulouse (France) Mots-Clés lipidomic workflow bioinformatics Description Context: Lipids are essential cellular constituents that have many critical roles in cellular functions. They are involved in energy storage, cell signaling as second messengers, and are major constituents of cell plasma membranes including lipid rafts (Simons and Toomre 2000). Their crucial role is highlighted by their involvement in a large number of heterogeneous diseases such as cancer, diabetes, neurological disorders and inherited metabolic diseases (Wenk 2005; Lamari et al. 2013). Abnormal concentrations of lipids are especially observed in various neurological disorders, including neurodegenerative conditions such as Alzheimer’s or Parkinson’s diseases and neurometabolic disorders (Han et al. 2002; Adibhatla et al. 2006; Colsch et al. 2008; Ariga et al. 2008; Haughey et al. 2010). In our lipidomic facilitiy, by combining liquid chromatography to high resolution mass spectrometry, we have developped a unbiased method that lead to the identification of lipid profil. This generation of large dataset need statistical and informatic skill to be analysed. Objectives: In this intership, the student will have mainly to develop a method to process unbiased lipidomic data obtained on a high resolution system through different informatics tools. Initially, the various software packages available will be evaluated and then the most suitable will be optimised to offer a new service on Metatoul_Lipidomique. The student will benefit from a dynamic environment rich in bioinformatics expertise at the MetaToul facility (https://mth- metatoul.com/) and the national MetatoboHUB infrastructure (https://www.metabohub.fr/metabohub.html). The student must be an analyst with a strong interest in bioinformatics tools or be a computer scientist with a desire to discover the exciting world of metabolomics! Contact person to apply : Justine Bertrand-Michel, justine.bertrand-michel@inserm.fr Tel : 06 71 68 16 50 Candidature Procédure : Contact person to apply : Justine Bertrand-Michel, justine.bertrand-michel@inserm.fr Tel : 06 71 68 16 50 Contacts Justine Bertrand-Michel juNOSPAMstine.bertrand-michel@inserm.fr Offre publiée le 14 novembre 2023, affichage jusqu'au 13 janvier 2024