Computational biologist in single cell OMICS applied to immuno-oncology
CDD · Postdoc · 36 mois (renouvelable) Bac+8 / Doctorat, Grandes Écoles The CISTAR Laboratory " Cancer Immune Surveillance and Therapeutic tARgeting" · LYON (France)
Date de prise de poste : 1 mars 2024
single-cell transcriptomic spatial analyses immuno-oncology
We are seeking a highly motivated and scientifically driven computational biologist/bioinformatician. The
candidate will bring his/her expertise to contribute to the team objective in identifying key immune surveillance
pathways operating in tumors using a unique strategy, based on the team advanced expertise on DC subsets,
combining single-cell transcriptomic and spatial analyses of innate immune cells at preneoplastic stages in
breast and colon environment.
Using both human tissue samples and spontaneous sporadic mouse tumor models, the team has generated
datasets along 2 axes:
- Deep single-cell RNA-sequencing of innate immune (DC, M, neutrophils, NK) and epithelial/stromal cell
compartments comparing normal, preneoplastic lesions and established tumors in order to define cell
trajectories during tumor progression and identify specific pathways activated at preneoplastic stage and
contributing to prevention of tumor development.
- Tissue localization of each innate immune cell population and identification of its neighbors by deep in situ
multi-IF spatial analysis with the aim to define the spatio-temporal crosstalk between innate and
The successful candidate will take the lead to integrate these 2 approaches through deep machine-learning
techniques representing a breakthrough strategy to pinpoint key cell/cell interactions and immune surveillance
pathways activated at early stage and interrupted in advanced tumors.
Procédure : Interested candidates should submit a motivation letter, CV and contact details of 2 references to Christophe Caux (Christophe.Caux@lyon.unicancer.fr)
Date limite : 15 décembre 2023
Dr Christophe Caux
Offre publiée le 15 novembre 2023, affichage jusqu'au 15 décembre 2023