Mots-Clés

Molecular modelling biosimulation enzyme molecular design artificial intelligence

Description

At CARBIOS, we make the impossible into reality through innovation. Our purpose? Enabling largescale circularity of plastics and textiles. For over 10 years, CARBIOS and its subsidiary CARBIOLICE have been dedicated to rethinking the end-of-life cycle of plastics and textiles. With world-leading technological advancements developed in France within our laboratories, we innovate for a more sustainable future. Supported by renowned partners and key industry players, we contribute to combating plastic pollution by demonstrating the feasibility of creating a new value chain. CARBIOS stands out as an innovative French group specializing in the development of enzymatic processes, committed to generating positive social and environmental impacts through its business project.

Join us in an exciting human, scientific, and industrial adventure towards a truly circular economy!

As part of our development, we are hiring a: Molecular Enzyme Modeling Specialist F/M

Job description:

The successful candidate will reinforce the teams working on the optimization of depolymerases of Polyethylene terephthalate (PET) as well as other polymers studied by the Innovation team (notably polyamides). He/she will be a key member of ambitious research projects focusing on the engineering of enzymes for degrading plastic polymers.

You will be mainly in charge of studying the structure/function relationships of enzymes of interest using a wide range of molecular modelling techniques. The development and implementation of computational tools adapted to specific needs of enzyme discovery and optimization will also be part of your mission. You will also be responsible for monitoring Artificial Intelligence-based projects.

Based on modelling results, you will be able to propose enzymatic engineering strategies and enzyme targets to the experimental team, and you will work in close collaboration with the I. André molecular modeling and design group of TBI's Enzymatic Catalysis and Molecular Engineering team. You will also monitor external modelling collaborations. You will report to the Director of Scientific Programs.

 

Your main tasks:

Working in close collaboration with Carbios' Scientific Management and team, and TBI's Enzymatic Catalysis and Molecular Engineering team, you will:

• Investigate structure/function relationships of enzymes of interest using molecular modeling and simulation techniques.

• Develop, set up and implement computational tools and methods adapted to the specific needs of enzyme discovery, optimization and studies.

• Propose enzyme engineering strategies and targets based on modeling results to the experimental team.

• Develop, set up and implement Artificial Intelligence tools adapted to the specific needs of enzyme engineering.

• Analyze experimental results using molecular modeling approaches.

• Collaborate with external molecular modeling teams.

• Liaise with biophysics specialists (Crystallography, NMR, etc.).

• Contribute to the drafting of reports, scientific presentations, articles and patents based on research results.

• Maintain a scientific and technical watch on subjects related to his/her activity.

 

Your profile and skills:

• PhD in molecular modelling or structural bioinformatics or related field.

• Solid expertise in molecular modelling and dynamics software.

• Protein structure prediction.

• Protein-ligand interaction studies (molecular docking, ...).

• Experience in computational protein design.

• Experience in QM/MM would be an asset.

• Programming skills (Python, C++, R).

• Experience in Artificial Intelligence would be a real plus.

• Ability to work as part of a team, communicate effectively and make propositions.

• Ability to manage several projects simultaneously and meet deadlines.

• Fluency in written and spoken English.

• Fluency in French would be an asset.

 

Your terms of employment:

• Open-ended contract

• Position based in Toulouse (France)

• Reporting line: Director of Scientific Programs

• Collective bargaining agreement: Chemical and related industries

• Working hours: 211-day package

• Remuneration: according to profile + PPV + Profit-sharing + 10% target bonus

• Mutual insurance / provident scheme

• Start date: September 2024

 

Are you interested in this opportunity?
Please send your application to: recrutement@carbios.com

 

3 good reasons to join Carbios Group:

1- We innovate for a better world At Carbios, nature is our source of inspiration.

We free up land and oceans by using plastic and textile waste as raw materials, thanks to our worldleading technological advancements.

We dedicate our time to researching new bio recycling and biodegradation technologies, and to developing revolutionary processes.

As pioneers in our field and owners of 58 patent families, we innovate for a more sustainable future.

2 – We go further, together

At CARBIOS, we are committed to preserving our planet and harnessing our expertise for tomorrow's challenges. Together, we act confident that our knowledge and initiatives whether individual or collective, will have a positive impact on our ecosystem. Every day, empowered by the strength of our collective, we progress daily with solidarity and mutual support. Our commitment and pride drive us ; our sense of solidarity and kindness fuel our growth. Motivated by our mission, we achieve success. Our teams standout for their diversity and inclusive spirit.

3 – We inspire by ambition

At CARBIOS, we are determined to lead with conviction and perseverance. Our industrial and biological contributions are crucial for the future of the next generations. Supported by renowned partners and major industry players, we address this global challenge by proving that creating a new value chain is achievable. Through the efforts of our teams, partnerships, and academic collaborations, we continually explore new frontiers. Our early discoveries and shared ambition drive us forward in this endless quest.