Mots-Clés

cancer genomics, computational biology

Description

Postdoctoral Fellow or a Computational Engineer

Gustave Roussy Institute

Position and Project title:

Postdoctoral position in bioinformatics or computational biology to study damage induced mutagenesis in cancer

Research environment and project

Gustave Roussy, the first European Cancer Centre, recruits a bioinformatics or computational biology postdoctoral fellow at U981 INSERM Unit, Group of Cancer Genomics led By Dr Sergey Nikolaev.

The project is dedicated to the study of damage induced mutagenesis in skin cancer and in other cancer types.

The postdoctoral fellow will have access to a unique molecular whole genome sequence dataset (DNA) for hundreds of skin tumors. Her/his mission will be to characterize mutational landscapes associated to different molecular mechanisms in order to improve our understanding mutational process in cancer. Unique data generated in the lab include genomic sequencing of (i) the cohort of patients with Xeroderma pigmentosum (XP), which are characterized by up to 1’000 fold increased cancer risk (ii) the large cohort of non-melanoma skin cancers (iii) in-vitro and in-vivo knock-out models of XP. Model building and validation will also exploit available public databases such as TCGA, ICGC, HARTWIG. 

Skills

Applicants should have experience in human genome data analysis, with a desire and capacity to acquire complementary expertise.

Valued skills for this position include: germline or somatic DNA variation analysis, statistical background.

The postdoctoral fellow will be self-motivated and able to work independently and get actively involved with colleagues of the Gustave Roussy bioinformatic teams.

Tasks

Process the whole genome sequencing data for 100s of cancer genomes and in-vitro and in-vivo models.

Describe mutagenesis in the context of mutational signatrues, and genomic features as transcriptional and replication bias, and epigenomic covariates.

Identify those features in large cohorts of sporadic cancers.

Perspectives

In order to apply to CNRS or INSERM starting grants, a solid doctoral and postdoctoral publication track record is necessary. The successful candidate will be supported on the longer term to apply for CNRS/INSERM starting grants and positions in order to establish his/her own research group at Gustave Roussy.

Qualifications : 

Ph.D. in bioinformatics, computational biology, biostatistics or machine learning.   

Contract type:

Initial fixed-term 18-month contract, with possible extension. Salary dependents on experience.  

For queries about this position, please contact: Sergey.Nikolaev@gustaveroussy.fr