Mots-Clés

NGS, Python, APIs, GUIs, Machine Learning, statistics

Description

DNA Script

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system.

To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo.

DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense.

DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco.

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionately eager people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a fast-paced company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.

The Role

DNA Script is actively searching for a software developer, Bioinformatics to join a small team providing bioinformatic support to the whole company.

The ideal candidate should be enthusiastic and passionate about bioinformatics and related technologies. We are looking for a team player who can rapidly adapt to challenges and interact with different teams as new projects arise. This position would be an excellent match for someone who is comfortable working with both biologists and developers to translate biological data into actionable insights.

We have many different teams within DNA Script who have bioinformatic requirements, and this role will include assisting in both the rapid turnaround of biological questions into insight, as well as running and maintaining already established pipelines and tools. Thus, the ability to juggle multiple projects, both short-term and long-term, is crucial.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

Main Responsibilities

• Be in charge of the analysis of NGS and other forms of sequencing data
• Development and maintain of APIs and graphical user interfaces (GUIs) for querying database content
• Design and implement relational databases
• Participate in the development of smart designs to facilitate synthesis and assembly of oligonucleotides
• Creating dashboards for data visualization and analysis
• Participate in the development and improvement of the bioinformatics side of commercial products
• Ensure consolidation, traceability and reliability of generated data and algorithms
• Operationally manage activities required to achieve key objectives linked to strategic partnerships
• Ensure comprehensive, clear and concise reporting of your activities
• Promote inter-teams collaboration
• Promote good coding practices 

Qualifications and Education Requirements

• Either a MSc degree in bioinformatics with at least 2 years’ experience of working in a related field
• Or a PhD in a related field (bioinformatics, computational biology)
• Direct experience working with NGS data
• Proficient in Python programming
• Experience in developing and maintaining bioinformatics tools, including databases, APIs, and graphical user interfaces (GUIs)
• Experience in developing interactive tools using technologies such as Flask and/or Shiny
• Comfortable in working to a high standard both independently and as part of a team
• Curious and analytical, with a proven ability to learn quickly
• Proficient in English and a basic level of French

Preferred Skills and Abilities

• Experience in using workflow languages (snakemake, Nextflow) to run pipelines
• Experience working in a cloud environment (e.g. AWS)
• Machine learning / Statistics
• Competence in working on a Linux command line
• Parallelization of computations on High Throughput Computing (HTC) systems.
• Experience with Docker/Singularity is a plus