Mots-Clés

Epigenetics Data integration Multi-omics Parkinsons Disease NGS Neurodegenerative Diseases

Description

Bioanalyst for the integrative analysis of “Epigenetic changes in Neurodegenerative diseases”

Laboratory for Epigenetics & Environment, CEA-CNRGH, Evry, CDD 30 months 

For its activity analyzing the human epigenome in sorted cell populations from patients with neurodegenerative diseases and the effect of different clinical treatments on the epigenome, the Laboratory for Epigenetics and Environment, led by Dr Jorg Tost, at the CEA – Centre National de Recherche en Génomique Humaine is recruiting a qualified bioinformatician/bioanalyst.

In the framework of an European JPND project (EU Joint Programme – Neurodegenerative Disease Research), we aim at integrating our own extensive datasets (DNA methylation, gene expression, microRNAs) with publicly available resources (NIH, MJ Fox foundation, Brain atlas). The candidate will re-annotate, analyze and integrate data from genome-wide DNA methylation, miRNA as well as RNA sequencing in patient samples with Multiple System Atrophy (MSA) and Parkinson’s disease and cellular systems in which key changes of the neurodegenerative diseases are reproduced with large-scale publicly available datasets (GWAS , scRNA_Seq) to provide new molecular targets of pharmaceutical intervention that will be tested by other partners of the consortium. He/she will leverage the value of the internal data sets by implementing and/or developing imputation approaches for large-scale epigenetic data. The candidate will participate in the procedures to gain access to external data sets and will guide and supervise junior members of the team in their related analyses. The successful candidate will participate and lead the valorisation of the results from the project through publications and presentations. 

The National Center for Research on Human Genomics (CNRGH in French) is located in the French Genopole, in Evry, near Paris. This research center is involved in major national and international research projects to study complex diseases according to different biological views (genetic, transcriptomic, epigenetics, ...) using high-throughput technologies (high density microarrays, NGS). The important flow of the biological data produced in the center implies automated data processing pipelines and the application of complex and integrative bioinformatics methods. The laboratory for Epigenetics and Environment is involved in the development and application of technologies to analyse DNA methylation and other epigenetic modifications at high resolution at target loci and genome-wide as well as the development of bioinformatic tools for the processing of such data. The main focus of the Epigenetics group has been the analysis of DNA methylation and miRNA patterns implicated in neurodegenerative and inflammatory diseases.

Type of contract: Fixed term contract (~ 30 months)

Salary: according to candidate's experience.

Limited remote work possible (1-2 days/week)

Education:

PhD in Bioinformatics (or a related discipline) required

Qualifications:

- Good knowledge of programming languages for the analysis of quantitative large-scale data.

- Proficiency in the R environment and usage of Bioconductor packages.

- Experience in the manipulation of large-scale data sets

- Experience in procedures for data access would be an asset

- Fluent English due to the international collaboration is a pre-requisite.