Société Française de Bioinformatique

Mots-Clés

Bioinformatique Neuroscience Génétique

Description

Understanding Rare Genetic Variation and Disease Risk: A Global Neurogenetics Initiative

Research project description

The analyses will be performed on cohorts of the general population and psychiatric population using cognitive, neuroimaging, and genomic data. The dataset includes between 100,000 and 800,000 individuals depending on the phenotypic measures. Genetic variants (CNVs and SNVs) will be identified from genotyping chip data and whole-genome sequencing. Functional annotation of genes will be conducted using transcription data, such as the topological distribution of gene expression in the brain and different cell types.