Mots-Clés

Phage, génome, métagénomique, génomique, comparative métagénomique, python, linux

Description

Subject: Skin Phageome Translational Analysis Internship.

Internship Master 2 (6 months)

From January/February to Juin/July 2025 at the EBI (Ecoles de bio-industries, Cergy 95800, France)

Human development and health have been improved by the advances and numerous studies on microbiome human. In contrast to microbiome research, the phageome is ignored. Phageome is a term used to describe bacteriophages, viruses that infect bacterial hosts. They are known to regulate the dynamics and diversity of bacterial populations in various ecosystems. Phages were first discovered in the early 1900s and were recognized as an alternative to antibiotic treatment. Most research concentrates on the use of phages for therapeutic and biotechnological purposes, but the analysis of phage communities is relatively young.

In this project, you will build a simulated dataset of phageome and explore the phage diversities based on different skin databases. In addition, you will optimize a bioinformatic workflow to process the metagenomics dataset (NGS) and explore the phageome of skin communities. Your task is to create an analytical workflow that can process a significant amount of NGS data. You will also use interactive and reproductible workflows and electronic notebook environments to analyze the data and ensure transparency, reproducibility, and reuse of the data analytical work.

Essential prerequisites for this role include robust competencies in Linux/Unix, and programming languages such as Bash, Python, and R. Additionally, skills in leveraging bioinformatics tools for quality control, alignment, and classification are crucial. An understanding with curiosity about metagenomics, genomics, and molecular biology will form the backbone of your contributions to this cutting-edge exploration.

CV and cover letter to p.le@hubebi.com.