Bioinformatician
CDD · Ingénieur autre · 12 mois (renouvelable) Bac+5 / Master Cancer Research Center of Lyon (CRCL) · Lyon (France)
Date de prise de poste : 3 février 2025
Mots-Clés
Pediatric Cancers Next Generation Sequencing Omics data analysis Organoids
Description
Bioinformatician position - C3 CELL-DEATH AND CHILDHOOD CANCER TEAM
Using Organoids & Bioinformatics to Address Tumoral Heterogeneity and Therapy Resistance
About the lab:
The establishment of cancer-derived organoids has recently begun to emerge as a prominent and
promising tool to enhance our understanding of human cancers (Broutier et al., nature protocols 2016 &
Broutier et al., nature medicine 2017). However, such models have as yet not been developed for pediatric
cancers. The research program that we develop in the C3 lab forms part of this perspective with the
objective to elaborate innovative organoid models to address pediatric cancers specificities and complexity,
with a special focus on the mechanisms of resistance to treatments. We are affiliated to the Cancer
Research Centre of Lyon (CRCL –INSERM U1052 / CNRS 5286) and to the Centre Léon Bérard’s Pediatric
hospital (IHOPE). Our group is therefore composed of researchers (biologists & bioinformaticians), clinicians
and pathologists.
Position Highlight:
Starting in February 2025.
The candidate will work with other bioinformaticians and biology researchers. In brief, the candidate will be
responsible for processing and analyzing multi-scale omics data: targeted-DNAseq, RNA-seq (bulk and
single cell (10X)), MethylEPIC 850K, and proteomics. The main focus of the candidate will be to explore, by
using these datasets, mechanisms of resistance to treatment in pediatric gliomas and rhabdomyosarcomas.
The key players identified by the candidate will be validated in the lab on organoid models. To ensure
reproducibility, analysis pipelines are being developed in the team. The candidate is expected to help
maintain and develop these pipelines.
Length/Period:
The successful applicant will initially have a 1-year contract, with the possibility of extension.
Salary:
Salary will follow the rules of the Cancer Research Center of Lyon (CRCL) and will depend on the experience
of the candidates.
Candidate profile:
- Holder of an engineering degree, M2, PhD in bioinformatics with a specialization in biostatistics
- Working experience in Next Generation Sequencing/Illumina technology analyses
- A good knowledge in statistics and in programming (R, linux/bash, python or perl)
- Knowledge in tools for pipeline development (snakemake, Nextflow) and versioning (git)
- Basic knowledge in cancer biology and genetics
Candidature
Procédure : Interested candidates should send a short curriculum vitae with a description of previous training & work experiences + a motivation letter to laura.broutier@lyon.unicancer.fr and flavie.benard@lyon.unicancer.fr. Please specify "BIOINFO_APPLICATION_" followed by your name in the subject line.
Date limite : 31 janvier 2025
Contacts
Laura Broutier
laNOSPAMura.broutier@lyon.unicancer.fr
Offre publiée le 20 décembre 2024, affichage jusqu'au 31 janvier 2025