Mots-Clés

single-cell omics cross-species comparisons pediatric brain tumor

Description

The Curie Institute Research Center

The Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness.

The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratories

The Genomics and Development of Childhood Cancers lab (https://institut-curie.org/team/saulnier), headed by Dr. Olivier Saulnier, and the Translational Research in Pediatric Oncology (RTOP) lab (https://institut-curie.org/team/bourdeaut_schleiermacher), headed by Dr. Franck Bourdeaut is looking for one postdoctoral researcher in bioinformatics on cancer/single-cell genomics.

We are located in the heart of Paris at Institut Curie, one of the world’s leading institutions in cancer research. It represents an excellent and international environment with interdisciplinary expertise and high-quality technological platforms.

Missions

The aim of the project is to understand the spatio-temporal origins of Atypical Teratoid/Rhabdoid Tumors (ATRT). Developmental origins of these intracranial tumors are poorly described. Thus, understanding mechanisms by which SMARCB1 defects promote tumor initiation and their physiological regulation during embryonic development is crucial. The successful candidate will use high-throughput single cell data to perform cross-species comparisons of ATRT tumors (human and mice) as well as normal embryonic development (human and mice).

Key publications

1/ Visvanathan*, Saulnier*, Chuan*, et al., Early Rhombic Lip Protogenin+ve Stem Cells in a Human Specific Neurovascular Niche Initiate and Maintain Group 3 Medulloblastoma. Cell 2024

2/ Lobón-Iglesias*, Andrianteranagna*, Han*, et al., Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups. Nature communications 2023

3/ Hendrikse*, Haldipur*, Saulnier*, et al., Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022

4/ Ho, Johann et al., Molecular subgrouping of atypical teratoid/rhabdoid tumors-a reinvestigation and current consensus. Neuro Oncology 2020

Training and experience required

• Training: Applicant should hold, or be in the process of completing, a PhD degree in bioinformatics or related areas
• Scientific skills: should have solid computational skills, and a strong interest in cancer biology, genomics and/or developmental biology
• Professional experience required: experience with single-cell omics

Skills required

• Language skills: very good English level and communication skills
• Ability to work independently, to communicate and to work in a team
• The candidate should be highly motivated, curious, and enthusiastic to work in a collaborative team

Type of contract: Fixed-term contract

Starting date: As soon as possible

Duration: 3 years (renewable)

Working time: full time

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris

Please send a CV with a list of publications, a motivation letter including past research and career goals, and contact information of at least two references to olivier.saulnier@curie.fr and franck.bourdeaut@curie.fr

Applications will be reviewed as received.